German Helmholtz Foundation GeneNetwork at the Helmholtz Centre for Infection Research (HZI), Braunschweig Germany, in the research group of Dr. Klaus Schughart.
Swiss GeneNetwork in the Laboratory of Integrative Systems Physiology lead by Dr. Johan Auwerx at the EPFL in Lausanne (initiated Nov 9, 2009)
Australian GeneNetwork mirror and development sites, Centre for Diabetes Research, University of Western Australia, in the research group of Dr. Grant Morahan (initiated May 2007)
Singapore GeneNetwork mirror site at the National University of Singapore, Bioinformatics Center, Dr. Mark De Silva (initiated Oct 2009)
California GeneNetwork mirror site in the Department of Genetics, University of California at Los Angeles, in the research group of Dr. A. Jake Lusis (initiated Aug 2008)
INRA IJPB, Versailles mirror site in the VAST lab of Dr. Olivier Loudet, Plant Breeding and Genetics Unit (initiated Dec 2008)
University of Memphis mirror sites in the Bioinformatics Program and research group of Drs. Ramin Homayouni and Mohammed Yazin (initiated June 2009)
Computable Genomix and the Semantic Gene Organizer systems are the source of GeneNetwork literature correlation data sets.
Custom Microarray Annotation Files used by GeneNetwork
Sanger Mouse Sequencing Portal (David Adams and colleagues)
StRAnGER Gene Ontology and KEGG pathway analyzer
GrAPPA Clique-based clustering tool
Harvester retrieves summary data on any one of 57, 000 proteins from several bioinformatic resources.
GSCAN: the Oxford Wellcome Trust Genome Viewer retrieves mapping data for many mouse experimental mapping populations including the Heterogenous Stock, the Pre-Collaborative Cross mice, and Mouse Diversity Panel.
NIF: The Neuroscience Information Framework retrieves summary from a wide variety of neuroscience and bioinformatic resources.
Genomics of aging resources. A collection of databases and tools designed to help researchers understand the genetics of human ageing through a combination of functional genomics and evolutionary biology.
Human Disease Gene Database from Cardiff (requires log in)
SNPnexus database of human SNPs is designed to simplify and assist in the selection of functionally relevant SNPs for large-scale genotyping studies of multifactorial disorders.
SNPedia is a wiki investigating human genetics. We share information about the effects of variations in DNA, citing peer-reviewed scientific publications. It is used by Promethease to analyze and help explain your DNA.
Genoglyphix Browser includes extensive data on human copy number variants as well as maps of low copy number repeat regions.
Human Protein Reference DB: a manually curated resource with data on 20, 000 proteins. Very effective interface and rich data.
x:map is a terrific visual display tool for exploring Affymetrix Exon array data sets for mouse and human transcriptomes.
iHOP retrieves PubMed sentences that report interactions between a reference gene and associate genes and proteins. It allows the assembly of complex graphs that plot the literature interactions of genes. Effective interface for humans and machines.
Human Protein Atlas displays expression and localization of proteins in a large variety of normal human tissues and cancer cells as high resolution images of immunohistochemically stained tissues and cell lines.
GoPubMed is a simple tool that searches PubMed and sorts the results by GO and MeSH terms.
AceViewand the Alternative Splicing and Transcript Diversity database provide excellent resources for systematic information about the many alternative transcripts produced from single genes.
MGI and RGD are reference sites for mouse and rat genetics, respectively.
GenAtlas provides summary data for approximately 19300 human genes and has a useful link that will fetch 10 Kb of upstream sequence for promoter analysis.
PromoLign aligns homologous regions of mouse and human promoters and highlights SNPs and transcription factor binding sites. Check the quick tutorial to see how to extract key data. This site requires an SVG plugin that may not be supported by some browsers and operating systems.
CGAP SNP Viewer allows users to view SNPs in the context of transcripts, ORFs and protein motifs for either human or mouse genes. Try the Ahr gene in mouse as an example.
*Synapse Database (SynDB) is a comprehensive database of genes and proteins associated with the neuronal or neuromuscular synapse. Many Trait Data and Analysis* pages provide links to SynDB.
Synapse Database at University of Pennsylvania is a comprehensive database of roughly 200 genes and proteins associated with the synapse.
Singapore Bio Databases and Tool.
MutDB and SNPs3D provide great data on functional SNPs in human genes. To analyze the functional impact of non-synonymous SNPs you will also find SNP Analyzer useful because it evaluates SNP impact in terms of the whole protein structural context.
Alternative Splicing Project provides great summaries and output graphs on splice variants in human, mouse, and Drosophila.
Resources on Imprinting and Parental Origin Effects
Geneimprint is a portal into the burgeoning field of genomic imprinting, collecting relevant articles and reviews, press reports, video and audio lectures, and genetic information
Catalogue of Parent of Origin Effects provides a list of imprinted and putatively imprinted genes with commentary by Ian Morison (University of Otago, New Zealand). Database was last updated in 2008.
Resources for the Spatial Analysis of Gene and Protein Expression
UBC Bioinformatic and Gene Expression Links is a very extensive and well curated collection of on-line resources for the analysis of biological data sets.
The mamep GeneExpression Links image database of whole-mounted in situ hybridization of mid-gestation mouse embryos. Try entering the symbol Ptch1.
The Genes to Cognition databases have a focus on proteins expressed in several key cellular compartments related to synpase function.
Cerebellar Development Transcriptome Database. Expression data for the mouse cerebellum, both microarray and in situ.
Several excellent resources can be used to explore patterns of gene expression primarily in C57BL/6J mice. This strain is one of the parents of the BXD, AXB/BXA, BXH, and CXB genetic reference populations that are key resources in the Gene Network and its companion site, the Mouse Brain Library.
BGEM and GENSAT provide images of gene expression in brains of embryos, neonates, and adult mice (roughly 2008 genes as of July 2005).
GenePaint and GeneAtlas are companion sites that also provide expression data in embryos, neonates, and adults at high spatial resolution. GeneAtlas has excellent but slow image searching and matching capabilities.
Allen Brain Atlas has expression data for ~12000 transcripts (adult males in the sagittal plane).
EMAP (Edinburgh Mouse Atlas Project) provides data on expression of ~800 genes during development (in situ, immunohistochemistry, and reporter knock-in expression patterns). Most data are from wholemounts between Theiler stages 11 and 20 (embryonic days E7 to E13). EMAP can be used as a Java WebStart application.
Mouse Atlas of Gene Expression is a massive SAGE library. The Atlas has quantified the normal state for many tissues by determining the number and identity of genes expressed throughout development. The scope of the project encompasses multiple stages of development of C57BL/6J mouse, from the single cell zygote to the adult, and includes an extensive initial collection of 200 tissues. DiscoverySpace is a WebStart application for use with The Mouse Atlas of Gene Expression.
Mahoney Center maintains a rich image collection for ~1000 transcription factors expressed in brain (developmental stages, coronal plane).
GeneMANIA helps you predict the function of your favourite genes and gene sets. Powerful and fast computational methods and a great use of Cytoscape Web. (2010 PDF).
ToppGene Suite A one-stop portal for gene list enrichment analysis and candidate gene prioritization based on functional annotations and protein interactions network
WikiPathways (WGCNA) is an open, public platform dedicated to the curation of biological pathways by and for the scientific community.
Pathway Commons (WGCNA) is a search tool to find and visualize public biological pathway information. This site collates from several major sites.
Sanger Mouse Genome Project SNP Finder provides access to SNP and indels generated by sequencing 17 strains of mice (plus C57BL/6J). Marvelous.
Weighted Gene Coexpression Network Analysis (WGCNA) is a collection of R functions to perform weighted correlation network analysis that includes functions for network construction, module detection, gene selection, calculations of topological properties, data simulation, visualization, and interfacing with external software. See the recent paper on WGCNA.
GenomeNet is a terrific site for the analysis of molecular networks. Download the very effective KegArray 0.2.6beta package (May 2005) for exploratory data analysis of microarray data set. This package is as good as most commerical software and includes with built-in linkage to the KEGG databases. Versions are available for Mac OS X and Windows.
Expression Profiler at http://ep.ebi.ac.uk/ is a set of tools for clustering, analysis and visualization of gene expression and other genomic data. Tools in the Expression Profiler allow you to perform cluster analysis, pattern discovery, pattern visualization, study and search Gene Ontology categories, generate sequence logos, extract regulatory sequences, study protein interactions, as well as to link analysis results to external tools and databases.
BioGRID: the Biological General Repository for Interaction Datasets is a freely accessible database of protein and genetic interactions from Mt. Sinai, Toronto.
CisMols Analyzer at Cincinnati Children's Hospital (Aronow and colleagues) is a server and database for the analysis of cis element co-occurences in the promoters of a list of genes. The PolyDoms Analyzer is a tool for scanning through gene lists for those members of a pathway, ontolog, or disease that contain potentially harmful protein-coding SNPs. GenomeTraFaC is a comparative genomics-based resource for initial characterization of gene models and the identification of putative cis-regulatory regions of RefSeq Gene Orthologs.
PolymiRTS database that searches for microRNA (miRNA) targets in transcripts that overlap SNPs. This database will also search for genes with associated phenotype variants that may have variants in miRNA target sequence (Yan Cui, Lei Bao and colleagues).
MSigDB: The Molecular Signature Database is part of the Broad Institute Gene Set Enrichment Analysis suite. MSigDB contains large numbers of static and partly annotated sets of genes/transcripts. Registration is not actually required to download data sets.
C-INIA MAGIC-B microarray knowledgebase from the Department of Pharmacology, University of Colorado, Denver, part of the NIAAA INIA project. Extensive public and privated brain array data sets in a powerful analytic web environment.
GenMAPP 2.0 (2004), the Gene Map Annotation and Pathway Prolifer, is a free Windows application (simple registration required) with which you can visualize expression and other genomic data sets on maps of biological pathways. Very flexible suite of programs that you can also use to make custom gene annotation maps (and more).
BIND and STRING and IntAct are great sites that provide access to well curated data on protein-protein interactions. BIND and IntAct focus on experimentally verified interactions whereas STRING and preBIND incorporate inferred interaction based on other data types, including gene expression. Links to BIND and STRING have been added to the Trait Data and Analysis forms on the GeneNetwork BETA site.[Added Aug 21, 2005; last site reviews Aug 27, 2005 by RWW.]
Microarray Module Maps is a great site that databases a large number of coexpression modules defined using many cancer array studies.
The Gene Ontology Consortium maintains a well annotated list of open resources for the analysis of large expression data sets and gene ontologies. Note that there are several different lists, each with valuable links.
Prioritizer: Prioritizer is a stand-alone Java program that uses a functional human gene network, available at www.genenetwork.nl, to prioritize positional candidate genes that reside within susceptibility loci, by assuming that real disease genes, residing within different loci are functionally closely related within the gene network.
eQTL Explorer is a Java WebStart application that has also been designed for the calculation and display of QTL maps for large rat data sets, particuarly those generated using the HXB strains. Locations of QTLs for both mRNA traits and conventional physiological traits are displayed on chromosome ideograms. High precision QTL maps can also be generated. A password is required to gain access to the primary data files.
Clique-GO Analysis is a novel tool for extracting cliques of coregulated transcripts. The current data requires Affymetrix U74Av2 probe set IDs as input. Try "103370_at" (the gene Lin7c) as an example.
[Added Jan 4, 2005; last site review Jan 4, 2005 by RWW.]
Gemma and ErmineJ are powerful resources for analysis and metaanalysis of gene expression data sets at UBC. Pavlidis and colleagues also provide updated GO data for common microarray platforms.
Cytoscape is one of several SBML-compatible open source programs for visualizing molecular interaction networks and overlaying these networks with gene expression profiles and other data sets to generate and test specific hypotheses.
[Added Jan 5, 2005; last site review Jan 5, 2005 by RWW.]
Pathway Searcher provides fast access to gene/protein interaction pathways. An intuitive interface.
[Added Dec 30, 2004; last site review Dec 30, 2004 by RWW.]
Gene Sorter is a tool for generating and sorting sets of genes using a wide variety of information integrated into UCSC's Genome Brower.
[Added Dec 31, 2004; last site review Dec 31, 2004 by RWW.]
oPPOSUM is a tool for finding over-represented transcription factor binding sites in lists of mouse and human genes. It handles about 100 out of greater than 600 TFBSs.
[Added Jan 27, 2005; last site review Nov 21, 2005 by RWW.]
MOTIF and PAINT search for motifs in submitted sequences or lists of genes. Paint makes use of the TRANSFAC Pro database.
[Added Dec 22, 2004; last site review Dec 25, 2004 by RWW.]
Arrowsmith provides a fast way to evaluate known interactions or common mechanisms between two genes or proteins. It carries out a sophisticated comparison of the current PubMed database.
Chilibot applies natural-language processing to the PubMed database to hunt for directed relationships among pairs or sets of genes, proteins, and keywords.
[Added Dec 30, 2004; last site review Aug 13, 2009 by RWW.]
Mouse Imprinting Resources: The Harwell Mouse Imprinting Resource, Duke University - Jirtle's Laboratory, RIKEN Candidate Imprinted Transcript Maps, and Imprinted Gene Catalogue - University of Otago. [Added Oct 20, 2006; last site review Oct 20, 2006 by RWW.]
[Added Dec 22, 2004; last site review Aug 6, 2005 by RWW.]
MPAD Mouse Phenome Association Database v 1.0, by Eleazar Eskin and Hyun Min Kang. This resource performs genome-wide association mapping. Phenotype data sets are derived from the Mouse Phenome Project set of standard mouse strains. The permutation procedures account for the genetic relations among these strains and provide much more appropriate genome-wide significance thresholds than previous mouse association mapping methods.
[Added Nov 19, 2006; last site review Nov 19, 2006 by RWW. Link broken June 2007 probably due to move from UCSD to UCLA; check with EE.]
GScan at the Wellcome Trust, Oxford, is a sophisticated viewer and analysis tool with which to explore the genetic control of diverse phenotypes (including array data) generated using heterogeneous stock mice (Flint, Mott, and colleagues).
[Added May 28, 2007 by RWW.]
Phenome Project provides access to a wide variety of phenotype data many common and wild inbred strains of mice.
[Added July 29, 2005; last site review Jan 7, 2006 by RWW.]
Positional Medline (PosMed) is a knowledge-based ranking system of candidate genes within QTL intervals for human, mouse, rat, Arabidopsis, and rice.
[Added Nov 4, 2009; last site review Nov 4, 2009 by RWW.]
Genome - Phenome Superbrain Project integrates various databases to build a comprehensive computerized encyclopedia of omic sciences in several species, including mouse, rat, human, and arabidopsis, etc. The goal is to evolve this intelligent system into a form of artificial intelligence that can solve a researcher's problems by exploiting a vast amount of information accumulated in documents and published data ranging from genomes to phenomes.
[Added Sept 13, 2007; last site review Sept12, 2007 by RWW.]
QTL Reaper is software, written in C and compiled as a Python module, for rapidly scanning microarray expression data for QTLs. It is essentially the batch-oriented version of WebQTL. It requires, as input, expression data from members of a set of recombinant inbred lines and genotype information for the same lines. It searches for an association between each expression trait and all genotypes and evaluates that association by a permutation test. For the permutation test, it performs only as many permutations as are necessary to define the empirical P-value to a reasonable precision. It also performs bootstrap resampling to estimate the confidence region for the location of a putative QTL.
QTLNetwork 2.0 is a software package ofr mapping QTLs with epistatic and GXE interaction effects in experimental populations including double-haploid, recombinant inbred, backcross, F2, IF2 and BxFy populations. The program provides graphical presentations of QTL mapping results. The software is programmed by C++ programming language under Microsoft Visual C++ 6.0 environment. It works with Microsoft Windows operating systems, including Windows 95/98, NT, 2000, XP, 2003server. A new version of QTLNetwork is under developing, and its functions will be extended to include linkage group construction and marker-assisted virtual breeding.
[Added June 21, 2007.]
MouseHapMap project genotypes from Mark Daly and colleagues. Approximately 140, 000 SNPs across 49 strains. Updated Feb 2006.used to explore the Oxford Wellcome Heterogeneous stock QTL mapping project population. It currently includes mapping data for 100+ phenotypes typed across 2000 animals and 13, 000 SNPs.
A valuable list of Software for QTL Data Analysis and Gene Expression Microarray Software is managed by Brian Yandell at University of Wisconsin.
[Added May 16, 2006; last site review May 16, 2006 by RWW.]
GSCAN DB is a browser used to explore the Oxford Wellcome Heterogeneous stock QTL mapping project population. It currently includes mapping data for 100+ phenotypes typed across 2000 animals and 13, 000 SNPs.
[Added May 10, 2006; last site review May 10, 2006 by RWW.]
The Wellcome Trust-CTC SNP Data Set consists of high density SNP data for approximately 490 strains of mice at 13, 377 SNPs. These data fiels were processed slightly to generate many of the mouse mapping files used in WebQTL.
The NIEHS-Perlegen Mouse Strain Resequencing Project provides links to SNP data for up to 15 strains of mice. Very high density data for many chromosomes. These data are integrated to some extent in the GeneNetwork.
This text originally generated by RWW, Dec 21, 2004. Updated by EJC, Feb 27, 2005; by RWW, July 15, Sept 25. Management of GeneNetwork access and trait pages
