Group |
Mouse: BXD group |
Tissue |
Hippocampus mRNA |
Gene Symbol |
Grin2b |
Aliases |
Wikidata: NR3; NMDAR2B; NR2B; DEE27; EIEE27; GluN2B; hNR3; MRD6; AW490526; Nmdar2b; GluRepsilon2 |
|
GeneNetwork: hNR3; NMDAR2B; NR2B; NMDAR2B; Nmdar2b; GluN2B; GluRepsilon2; AW490526; MRD6; hNR3 |
Location |
Chr 6 @ 135.798431 Mb on the minus strand |
Summary |
Enables NMDA glutamate receptor activity and calcium channel activity. Involved in negative regulation of dendritic spine maintenance. Acts upstream of or within several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Located in several cellular components, including cytoplasmic vesicle; lysosome; and synaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Oct 2024] |
Database |
UMUTAffy Hippocampus Exon (Feb09) RMA
|
Target Score |
BLAT Specificity
:
1.018
Score: 72.000
|
Resource Links |
Gene
OMIM
GeneMANIA
Protein Atlas
Rat Genome DB
GTEx Portal
UCSC
BioGPS
STRING
PANTHER
Gemma
ABA
EBI GWAS
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