Group |
Mouse: BXD-Longevity group |
Tissue |
Liver Proteome |
Gene Symbol |
Tfam |
Aliases |
Wikidata: MTTF1; TCF6L1; MTDPS15; MTTFA; TCF6; TCF6L2; TCF6L3; AI661103; Hmgts; mtTFA; tsHMG; Mttfa |
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GeneNetwork: AI661103; Hmgts; mtTFA; tsHMG |
Location |
Chr 10 @ 71.225464 Mb on the minus strand |
Summary |
Enables mitochondrial promoter sequence-specific DNA binding activity. Involved in mitochondrial transcription. Acts upstream of or within mitochondrial respiratory chain complex assembly. Located in mitochondrial nucleoid. Is expressed in several structures, including brain; branchial arch; early conceptus; genitourinary system; and hemolymphoid system. Used to study Kearns-Sayre syndrome and Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022] |
Database |
EPFL/ETHZ BXD Liver Proteome CD-HFD (Nov19)
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Resource Links |
Gene
GeneMANIA
Protein Atlas
Rat Genome DB
GTEx Portal
UCSC
BioGPS
STRING
PANTHER
Gemma
ABA
EBI GWAS
UniProt
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